Drug Toxicology Safety and Metabolism

GSK Undergraduate Industrial Placement Job Title: Drug Toxicology, Safety and Metabolism
Reference Number: 1032d

Salary: Competitive 

Degree Requirements: Must be on track for a 2.1 or above in an undergraduate degree in biology or chemistry discipline.

You will have completed a minimum of 2 years of an undergraduate degree, but will not have graduated at the start of your placement. 

Location:  Ware (Hertfordshire)

Detailed description and scope of the role:

Mechanistic Safety and Disposition (MSD) at GSK R&D is an integrated scientific community focussed on the development of tomorrow’s medicines.  The role of the Division is to conduct pre-clinical studies to understand the levels of drug exposure that represent a risk to human health, enabling safe clinical trials and drug registration via pre-clinical hazard identification and risk assessment.
These industrial placement opportunities are available within the Investigative Safety and Drug Metabolism (ISDM) and Investigative Safety and Drug Disposition (ISDD) departments in MSD, based at our state of the art research facilities in Ware, Hertfordshire.  Here you will get the opportunity to learn more about toxicology, drug metabolism and the drug discovery process, whilst working across matrix teams employing the most advanced research techniques.

Within ISDM & ISDD a number of strategies are employed to investigate drug-related effects in pre-clinical studies and to facilitate our understanding of drug metabolism and pathological responses to toxicological injury.  To achieve this we develop and validate bespoke assays and models in response to emerging safety liabilities, to help characterise the underlying mechanisms of toxicity. In addition, we seek to understand and characterise the fate of the drug molecule in in vitro models, animals and man with regards to efficacy and safety.  Drug molecules investigated include novel biopharm molecules, such as oligonucleotides and proteins, in addition to traditional small molecules.  

The aims of the project will be focussed and aligned to the requirements determined by individual drug development programmes and/or current attrition reduction interests in either drug metabolism or investigative safety.  During the placement the student can expect to gain experience in a variety of current techniques, these may include: in vitro models, cell culture, biochemical assays, HPLC, flow cytometry, imaging.

The work will be primarily laboratory based and full training will be provided.  The student will be expected to work in accordance with standard operating procedures (SOPs) and protocols and in compliance with GSK policies and safety procedures.  Progress of research conducted will be regularly communicated by presentations at group and departmental meetings, as required, and a written report will be required at the end of the placement.

Additional Details: PLEASE NOTE:  The Assessment Centre for successful applicants is expected to be in November/December 2018. 

Closing date for applications: Sunday 21st October 2018 

If you have what we’re looking for apply today!

We recruit on an on-going basis and prioritise applications based on the application date.  

We will close for applications when we have filled our assessment centre dates.

This opportunity has the following recruitment stages you must successfully pass to be offered a placement year with GSK for 2019!
1. Eligibility Form
2. Online Assessment
3. Application Form
4. Assessment Centre