Biology In Vitro/In Vivo Translation​

Please read below about the positions we are recruiting for, when you apply you will be able to select 3 preferences. We will accommodate your preference where possible.

GSK Undergraduate Industrial Placement Job Title: Biology In Vitro/In Vivo Translation

Reference Number: 1050e


Salary: Competitive

Degree Requirements: Must be on track to obtain a 2.2 or higher in a relevant Life Sciences undergraduate degree.

You will have completed a minimum of 2 years of your undergraduate degree but will not have graduated at the start of your placement.

Locations:  Stevenage, Ware

Scope of the roles:

GSK are a science-led global healthcare company that researches and develops innovative Pharmaceuticals, Vaccines and Consumer Healthcare products. Our challenging and inspiring mission is to enable people to do more, feel better and live longer by developing innovative products and improving access to healthcare for patients around the world. Our roles are primarily laboratory based, these provide an opportunity to support development of novel medicines to treat life-threatening disorders, putting the patient at the forefront of everything we do.

Whatever the role, you will experience working in a fast-paced research environment with access to cutting edge technology, whilst interacting with industry-leading scientists across multiple disciplines and sharing different experiences. During the internship, the IP student will be supported and given training (laboratory and office practices) on a daily basis where applicable until confident to work independently and within GSK health and safety requirements. The student will also be enrolled in several GSK internal courses as part of company policy (this include GSK values, data integrity, to use internal electronic lab book, laboratory safety rules, etc...). In addition, GSK also provides personal development courses and networking opportunities throughout the year in which the IP student can enrol.

IVIVT function as a Clinical Translation Platform supporting the Research Units within the Research, Oncology, and Global Health organisations. The team will provide expertise in nonclinical models, bioimaging, DMPK, bioanalysis, biomarkers, immunogenicity, safety, and drug disposition in support of nonclinical and clinical studies spanning target identification through post-approval of medicines.

 

Please read below about the positions we are recruiting for, when you apply you will be able to select 3 preferences. We will accommodate your preference where possible.

Role 1: Exploratory Biomarker Scientist

We have an exciting position working in the Exploratory Biomarker Assay Group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) division. The role of the Exploratory Biomarker Scientist is to work closely with pre-clinical and clinical project teams to define and deliver biomarker strategies to support translation of GSK’s rapidly expanding biopharmaceutical and small molecule portfolio into successful early phase clinical studies.

Working as part of a dedicated biomarker team, your role will be to develop and validate new biomarker assays to assess target expression, engagement and pharmacodynamic drug effects. This placement provides the opportunity to work on a broad spectrum of techniques and technologies, including Meso-Scale Discovery, ELISA, flow cytometry and imaging as well as working across multiple disease areas.

Our aim is to develop students to be highly independent in planning, executing and interpreting scientific data as well as presenting results and collaborating with other scientists. Working within the Exploratory Biomarker Group also provides ample access to scientific presentations and seminars as part of the vibrant Stevenage GSK science hub.

Location: Stevenage, Hertfordshire

 

Role 2: Toxicology and Pre-Clinical Safety

Mechanistic Safety Sciences (MSS) at GSK R&D is an integrated scientific community focused on the development of tomorrow’s medicines.  The role of the Division is to conduct pre-clinical studies to understand the levels of drug exposure that represent a risk to human health, enabling safe clinical trials and drug registration via pre-clinical hazard identification and risk assessment. 

This industrial placement opportunity is available within the Investigative Safety department within MSS, based at our state of the art research facilities in Ware, Hertfordshire.  Here you will get the opportunity to learn more about toxicology, immunology, cell biology and the drug discovery process, whilst working across matrix teams employing the most advanced research techniques.

Within Investigative Safety a number of strategies are employed to investigate drug-related effects in pre-clinical studies and to facilitate our understanding of pathological responses to toxicological injury.  To achieve this we develop and validate bespoke assays and models in response to emerging safety liabilities, to help characterise the underlying mechanisms of toxicity. In addition, we seek to understand and characterise the fate of the drug molecule in in vitro models, animals and man with regards to efficacy and safety.  Drugs investigated include immunotherapies, novel biopharm molecules, such as oligonucleotides and proteins, in addition to traditional small molecules. 

The aims of the project will be focussed and aligned to the requirements determined by individual drug development programmes and/or current attrition reduction interests.  During the placement the student can expect to gain experience in a variety of current techniques, these may include: in vitro models, cell culture, biochemical assays, HPLC, flow cytometry, imaging.

The work will be primarily laboratory based and full training will be provided.  The student will be expected to work in accordance with standard operating procedures (SOPs) and protocols and in compliance with GSK policies and safety procedures.  Progress of research conducted will be regularly communicated by presentations at group and departmental meetings, as required, and a written report will be required at the end of the placement.

Location: Ware, Hertfordshire

 

Role 3: Preclinical imaging scientist

We have an opportunity for an Industrial Placement, In Vivo Imaging Scientist to take up a one year placement commencing in August 2020. This role will be within the in vivo Bioimaging group based in Stevenage and is a varied role with opportunities to gain an insight into many therapeutic areas that align with the company strategy as well as key functions within the research and development (R&D) process.

The in vivo Bioimaging unit consists of several non-invasive imaging modalities (such as magnetic resonance [MRI], computerised tomography [CT] and optical) all of which play an important role in understanding the variety of key processes of R&D such as lead identification, optimisation and safety of our molecules. Core tasks involved in this role include liaising with scientists, organising imaging studies, performing routine imaging, as well as processing data and preparing presentations. Further opportunities may also exist to gain experience in other functional areas within the wider Bioimaging department, that may include ex-vivo imaging. In addition, there may be opportunity to gain practical experience of animal procedures during these studies.

Location: Stevenage, Hertfordshire


Role 4: Cell Dynamics & Imaging Biologist

The Bioimaging department was formed in 2016 and brings together key areas of in-vivo and ex-vivo imaging to understand drug distribution and the effect of that distribution on intact biological systems. The focus of the newly formed Ultrastructural and Cellular Bioimaging group is to support all aspects of Research, and the wider GSK, using Bioimaging at cellular & ultrastructural resolutions. As well as using existing modalities we keep aware of developing technologies and analytics through an extensive internal and external network. We work closely with in vivo, clinical and MALDI Bioimaging, making use of resources available across R&D and as such you will learn and develop the skills needed to interact with teams and scientists at all levels. The ability to determine the distribution of unlabelled drug related material and endogenous metabolites at cellular resolutions give us the ability to address key factors for compound efficacy and safety.

You will work as part of the Cell Imaging & Dynamics group within the Ultrastructural and Cellular Bioimaging team based in Stevenage, the GSK UK Science Hub, to provide critical mass spectrometry imaging data to progress the development of new medicines across a range of programmes supporting the numerous therapeutic areas within GSK. The team continues to pioneer leading edge technology through extensive external collaborations and to develop these approaches to deliver enhanced knowledge of compound distribution and its concomitant outcomes on biological processes. Your role will contribute to this advancement, with a particular focus on the application of advanced mass spectrometry, a highly desired skill set in biological analysis. You will learn to use cutting edge technology to study the uptake of compounds into cells and determine the effect such perturbations have on the underlying biology. This placement will give you training on the use of mass spectrometry to identify endogenous and exogenous molecules from individual cells, sampling from live cells and both optical and mass spectrometry imaging at cellular and sub cellular resolutions. In addition you will perform cell culture and live cell imaging.

 

Additional Details: The Assessment Centre for successful applicants is expected to take place in November 2019

Closing date for applications: Wednesday 16th October 2019

We recruit on an on-going basis and prioritise applications based on the application date.  

Applications will close when we have filled our assessment centre dates.

If you have what we’re looking for apply today!

This opportunity has the following recruitment stages you must successfully pass to be offered a placement year with GSK for 2020!

1.       Eligibility Form

2.       Online Assessment

3.       Application Form

4.       Assessment Centre​​
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