GSK Undergraduate Industrial Placement Job Title:  Biologist
Reference Number: 1044d 

Salary: Competitive

Degree Requirements: Must be on track for a 2.1 or above in a Life Sciences undergraduate degree in Pharmacology, Immunology, Biological Science, Biochemistry or Biomedical Science.

You will have completed a minimum of 2 years of your undergraduate degree, but will not have graduated at the start of your placement. 

Location:  Stevenage

Detailed description and scope of the role:

Investigate and characterize Protac pharmacology in autoimmune and oncology indications

Proteolysis-Targeting Chimeras (Protacs) are bifunctional molecules which simultaneously bind a target protein and an E3 ubiquitin ligase. The resultant ternary complex allows efficient ubiquitin transfer from the ligase complex to the target protein which is subsequently recognised by the proteasome and rapidly degraded. PROTACs can be used to introduce new pharmacologies for drug discovery programmes (i.e. duration of action, non-kinase functions) and tackle undruggable proteins by transforming a low binding ligand into a potent degrader. The project will support ongoing drug discovery efforts exploring PROTAC compound pharmacology across a variety of cell and tissue systems relevant to autoimmune or oncology indications

The aim is to support current studies within the DPU by conducting laboratory experiments and generating data to help determine the project direction. In addition, the student will be encouraged to review the relevant literature associated with the project and keep up to date with new findings in order to introduce new ideas/concepts to the project team. In addition, our DPU aims to train the student with the right skills to allow them to become independent in a wide range of laboratory techniques and improve their ability to plan, design and execute experiments independently. Also, the student will be gaining experience in maintaining accurate records of data according to GSK guidelines and will be expected to present and discuss data during team meetings and to a wider audience.

During the internship, the IP student will be supported and given training (laboratory and office practices) on a daily basis until confident to work independently and within GSK health and safety requirements. The student will also be enrolled in several GSK internal courses as part of company policy (this include GSK values, data integrity, to use internal electronic lab book, laboratory safety rules, etc...). In addition, GSK also provides personal development courses and networking opportunities throughout the year in which the IP student can enrol. The IP student will also have the opportunity to attend seminars by GSK scientists, which run throughout the year and comprise a wide range of areas within drug discovery

Additional Details: PLEASE NOTE:  The Assessment Centre for successful applicants is expected to take place week commencing 5th November 2018

Closing date for applications: Sunday 21st October 2018 

If you have what we’re looking for apply today!

We recruit on an on-going basis and prioritise applications based on the application date.  

We will close for applications when we have filled our assessment centre dates.

This opportunity has the following recruitment stages you must successfully pass to be offered a placement year with GSK for 2019!
1. Eligibility Form
2. Online Assessment
3. Application Form
4. Assessment Centre