Adaptive Immunity Research Unit - Multiple adverts

Please note, this advert contains different positions we are recruiting for across our Adaptive Immunity research unit. When you apply you will be able to select 3 preferences. We will accommodate your preference where possible.

 

GSK Undergraduate Industrial Placement Job Title: Adaptive Immunity Research Unit

 

Reference Number: 1049e

 

Salary: Competitive

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Degree Requirements: Must be on track for a 2.2 or above in Life Science undergraduate degree in Biochemistry, Biological Sciences, Biomedical Sciences, Immunology or Pharmacology. You will have completed a minimum of 2 years of your undergraduate degree but will not have graduated at the start of your placement. You will be expected to provide evidence from your university to show you will be an undergraduate student for the duration of the placement year.

 

Location(s): Stevenage, Hertfordshire

 

Duration: 1 year (approximately)

 

Scope of the roles

Adaptive Immunity relies on the coordination and expansion of specific adaptive immune cells. Immune memory follows the adaptive response, when mature adaptive cells, highly specific to the original pathogen, are retained for later use. The Adaptive Immunity Research Unit at GSK is positioned to optimise our opportunities in this exciting area of research. Additionally the team has access to unprecedented genetic resources through GSK’s collaboration with 23andMe, FinnGen and Open Targets combined with cell specific epigenetic datasets and functional genomic screens to identify pathogenic cell types, pathways and targets.

 

The group is made up of five large teams focused on different aspects of adaptive immunity from integration of genetic and functional genomic target validation approaches through to immuno-regulation, myeloid-adaptive cell communication, tissue and adaptive immune cell interactions and translational models.

 

Positions are available within different teams and descriptions of the type of work undertaken by these groups is provided below.

 

Please read below about the different positions we are recruiting for across Adaptive Immunity. When you apply you will be able to select 3 preferences. We will accommodate your preference where possible.

 

 

Research Group 1: Immunoregulation (4 positions available)

 

An imbalance between pathogenic effector and regulatory- (Treg) T-cells is a key driver for the initiation and chronicity of chronic inflammatory diseases. Within the Adaptive Immunology Research Unit, Biology Group 1 (Immunoregulation) is focussed on strategies to induce stable T-regs that are critical for immune homeostasis, tolerance and control of pathogenic T-cell responses. Rebalancing these aberrant immune responses by depleting pathogenic T-cells or increasing the number or activity of highly suppressive Tregs are scientific strategies that could lead to disease remission.  We use a wealth of genomic data alongside in-depth molecular phenotyping of tissue from a variety of chronic inflammatory diseases to characterise novel targets and pathways involved in regulatory cell biology.

 

As an IP student in Biology Group 1 you will have the opportunity to work alongside multidisciplinary scientists on projects encompassing; the identification of novel drug targets, the validation of the biology of drug targets and the development of innovative assays to support a drug target. You will be trained by an individual supervisor who will support your development throughout the year and you will be based within an  open-plan, state-of-the-art collaborative research lab, fully integrated in a team of world-leading immunologists and cell and molecular biologists.  In addition to an introductory training course covering the basics of drug discovery, you will have the opportunity to learn a number of lab techniques throughout the year such as: primary human cell and tissue isolation, cytokine & immune cell profiling through flow cytometry, ELISA and MSD, transcriptomic analysis of cells by qPCR and many others. In addition to these techniques you will have access to state-of-the-art technologies such as top of the range flow cytometers, the Imagestream, high content imagers, automated qPCR and western blots.  Throughout the year you will develop skills in autonomously planning, organising, and performing practical experiments and the subsequent reporting and presenting of your data to influence the direction of our lead programs. 

 

Research Group 2: Cell-cell communication and tissue homeostasis (3 positions available)

Research conducted within the Adaptive Immunity Research Unit Group 2 focuses on understanding cell: cell communication and priming of the adaptive immune system. Our group provides drug discovery expertise in biology, immunology and pharmacology and are particularly interested in understanding how targeting the myeloid lineage can modulate the immune system. To ensure that we undertake cutting-edge science and that we are leaders in our scientific field, our departments consists of highly motivated and skilled scientists with exceptional publication and drug discovery records. Furthermore, we have established outstanding links and collaborations, both internally at GSK and with renowned academic groups.

 

As an Industrial Placement student, the research you conduct will support an active drug discovery programme where you will be given the opportunity to be trained by experienced scientists in a variety of laboratory techniques. In addition to the standard cell and molecular biology techniques, we have access to many state of the art technologies such as CRISPR methods, Seahorse metabolic analysis and Aurora flow cytometers. Depending on your project you will be exposed to techniques such as primary leukocyte isolation and characterisation; flow cytometry, RT-PCR and Western Blot for the quantification and functional analysis of white blood cells; ELISA/MSD/Luminex for protein quantification; metabolic analysis of primary white blood cells; proliferation and apoptosis assays; cell culture and transfections; or protein knock out using CRISPR.

 

We offer an outstanding training programme where you will experience a range of laboratory techniques that are applicable to modern drug discovery. By the end of the placement you would have gained sufficient experience to be autonomous in designing and conducting experiments, document and report your scientific findings and understand how a large multidisciplinary team interacts. You will also be able to effectively drive the direction of your project, conduct literature reviews and determine how your results fit in with the ‘big picture’. Furthermore, you will gain valuable transferable skills such as effective communication, time management and organisational skills.

 

Research Group 3: Barrier Dysfunction and B Cell Biology (3 positions available)

 

This group focuses on targets aligned to barrier immunity and B-cells. Maintenance of a healthy immune defence at barrier sites requires a careful balance between effectively recognizing and responding to pathogenic challenge and, at the same time, co-existing with site-specific commensal microbiota. Additionally, barrier sites need the ability to resolve inflammation and promptly repair in response to injury. Failure in any of these functions can lead to severe chronic immune disorders or indeed, the development of tumors.. The interaction between epithelial cells lining the barrier sites and  immune cells is key in regulation of the barrier response. We are working on novel biology to further understand barrier immunity in the context of disease, with the aim to identify drug targets to correct impaired mechanisms.

 

As an IP student in Biology Group 3 you will have the opportunity to work alongside multidisciplinary scientists on projects encompassing; the identification and validation of the biology of novel drug targets, and the development of innovative assays to support a drug target. You will be trained by an individual supervisor who will support your development throughout the year and you will be based within an  open-plan, state-of-the-art collaborative research lab, fully integrated in a team of world-leading immunologists and cell and molecular biologists.  In addition to an introductory training course covering the basics of drug discovery, you will have the opportunity to learn a number of lab techniques throughout the year such as: primary human cell and tissue isolation, cytokine & immune cell profiling through flow cytometry, ELISA and MSD, transcriptomic analysis of cells by qPCR, confocal and high content microscopy, microbiology and virology, and many others. In addition to these techniques you will have access to state-of-the-art technologies such as top of the range flow cytometers, the Imagestream, high content imagers, automated qPCR and western blots.  Throughout the year you will develop skills in autonomously planning, organising, and performing practical experiments and the subsequent reporting and presenting of your data to influence the direction of our lead programs. 

 

Research Group 4: Genomic Immunology (1 position available)

The Genomic Immunology group, positioned within the larger Adaptive Immunity RU team, has access to unprecedented genetic resources through GSK’s collaboration with 23andMe, FinnGen and Open Targets combined with cell specific epigenetic datasets and functional genomic screens to identify pathogenic cell types, pathways and targets. The team will progress new targets and disease mechanisms identified through access to large genetic datasets and output from functional genomic screens. Using our genetic and mechanistic understanding we will seek to align our therapeutic opportunities to the best clinical indications.

 

As an IP you will contribute to validation of targets from the 23andMe collaboration with a focus on restoring tissue homeostasis and immune system regulation. As well as pursuing functional genomics and genetic approaches for target validation using in silico analyses and gene editing methods. The successful candidate will need to have excellent interpersonal skills, being able to work effectively in a multidisciplinary team as well as independently under general supervision and to interact positively and effectively with collaborating scientists within GSK. Understanding of immunology, genomics and drug development is highly desirable.Within this group you will gain comprehensive experience in experimental design, execution, assay development and analysis. Hands-on practical skills in immunological, cell and molecular biological, biochemical and computational techniques will be developed, e.g. primary immune cell isolation and manipulation, multi-parameter flow-cytometry, gene expression analyses, secretome immunoassays and programming (R, Python). You  will have exposure to lead experts in drug development, cutting edge technology and will undoubtably benefit from a diverse and collaborative environment at GSK.

 

Research Group 5: Experimental Quantitative Pharmacology (eQP) (2 positions available)

Experimental Quantitative Pharmacology (eQP) is part of the Adaptive Immunity Research Unit (AI-RU), we apply an integrated multi-disciplinary approach to solve specific, complex, multivariant problems to progress drug discovery. eQP is responsible for organising and carrying out in vivo and ex vivo work including translating data to inform clinical progression. The group is formed of scientists with a wide range of backgrounds including immunology and cell and molecular biology who work closely with bioanalysis and modelling scientists and in vitro scientists to support the adoption and advance of drug discovery programs.

As an IP student you will have the opportunity to work alongside multidisciplinary scientists on projects within any of the biology groups in the AI-RU and could include work on myeloid, T- and B- cells, cell:cell communication, and barrier dysfunction.

Based within our state-of-the-art collaborative research lab you may also have the opportunities to work in the dedicated animal facility. Working alongside our group you will be trained in a range of in vitro and ex vivo laboratory techniques used in modern drug discovery including cell isolation and culture, and molecular techniques such as ELISA and flow cytometry. Using these techniques to aid the validation of in vivo targets; investigate the action of novel compounds; gain in depth knowledge of, and refine pre-clinical models; and assess in vivo biomarkers suitability as clinical endpoints for patients. You will be given the opportunity to plan and conduct experiments, draw conclusions and present important decision driving data in group and program meetings developing a wide range of soft skills.

 

Research Group 6: Immuno-Epigenetics Placement Advert (6 positions available)

We are looking for highly motivated Industrial Placement students to join us in the Immuno-Epigenetics research unit based at Stevenage for one year starting in September 2020.  Our focus in this exciting and fast-moving field, is to target the function of the immune system through modulation of the proteins which read, write or erase the epigenetic code, in order to develop new medicines for immune mediated diseases.

You will be fully integrated into a team of highly motivated and talented scientists with an exceptional publication and drug discovery record, who work across drug discovery from the initial stages of target identification to early clinical development. You will spend your placement in a stimulating training environment which will allow you to learn a wide range of techniques that are used in modern drug discovery programmes, as well as obtain an in-depth knowledge of the drug discovery process in a leading pharmaceutical company. You will work on your own research project with support from both your supervisor and team. This will provide you with the opportunity to develop a wide range of skills in areas such as data analysis, presentations and laboratory techniques whilst extending your knowledge in the areas of the immune system and epigenetic mechanisms. 

 

Depending on your exact project, you will be investigating the function of human immune cells, including T cells, B cells, dendritic cells and macrophages, and applying a range of techniques which are currently utilised in our research unit.  These include whole blood derived cell isolation and culture, cell transfection, flow cytometry, quantitative gene analysis, protein quantification by ELISA, MSD, Luminex or Western blotting, epigenetic signalling including ChIP (chromatin immunoprecipitation) and ChIP-Seq, as well as CRISPR.

We look forward to receiving your applications!

 

 

Additional Details: The Assessment Centre for successful applicants is expected to take place in November 2019

 

Closing date for applications: Sunday 13th October 2019

 

We recruit on an on-going basis and prioritise applications based on the application date.  

 

Applications will close when we have filled our assessment centre dates.

 

If you have what we’re looking for apply today!

 

This opportunity has the following recruitment stages you must successfully pass to be offered a placement year with GSK for 2020!

 

1.       Eligibility Form

2.       Online Assessment

3.       Application Form

4.       Assessment Centre​


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